Phase II study of recombinant antitumor and antivirus protein injection compared with placebo in metastatic colorectal cancer after failure of standard treatment
R Jia, Y Wang, XY Mao, SS Li, N Xu, JP Xiong… - The …, 2015 - academic.oup.com
… status can still tolerate subsequent treatment. Recombinant antitumor and antivirus protein
(Novaferon) is an interferon-like protein that exhibited significant inhibition of cancer cells in …
(Novaferon) is an interferon-like protein that exhibited significant inhibition of cancer cells in …
OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma
HL Kaufman, SD Bines - Future oncology, 2010 - Future Medicine
… injection or recombinant GM-CSF (n = 120) by subcutaneous … in the Phase II clinical trial, a
Phase III clinical trial has been … of anti-tumor activity in the face of a vigorous antiviral immune …
Phase III clinical trial has been … of anti-tumor activity in the face of a vigorous antiviral immune …
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles
F Kratz - Journal of controlled release, 2008 - Elsevier
… antinociceptive, antidiabetes, antitumor or antiviral activity: Levemir… A phase II study against
small cell lung cancer will be … protein with recombinant interleukin-2 that has sown promising …
small cell lung cancer will be … protein with recombinant interleukin-2 that has sown promising …
IL-1α and colorectal cancer pathogenesis: enthralling candidate for anti-cancer therapy
… subsequent studies, the group has developed recombinant … Open label phase II study (NCT02090101)
evaluated the … in the phase III study of Bermekimab versus placebo (each with …
evaluated the … in the phase III study of Bermekimab versus placebo (each with …
Oncolytic viral therapies
E Lin, J Nemunaitis - Cancer gene therapy, 2004 - nature.com
… This review will focus on the anticancer activity of oncolytic viruses … for viral DNA replication
by blocking host cell antiviral … Two other trials involving colorectal cancer patients with liver …
by blocking host cell antiviral … Two other trials involving colorectal cancer patients with liver …
The interferons: mechanisms of action and clinical applications
S Baron, SK Tyring, WR Fleischmann… - Jama, 1991 - jamanetwork.com
… and \g=g\),which then induce the antiviral, antimicrobial, antitumor, and … The recombinant
IFN-as are both a single molecular … colorectal carcinoma,99 IFN- plus dacarbazine in advanced …
IFN-as are both a single molecular … colorectal carcinoma,99 IFN- plus dacarbazine in advanced …
Therapeutic potential of anticancer immunotoxins
S Choudhary, M Mathew, RS Verma - Drug discovery today, 2011 - Elsevier
… poke weed antiviral protein, are used in immunotoxin constructs [2]. … A Phase II study is
performed on larger groups (20–300 … lesions of metastatic breast cancer, colorectal cancers and …
performed on larger groups (20–300 … lesions of metastatic breast cancer, colorectal cancers and …
Trial watch: peptide-based vaccines in anticancer therapy
… agents technically represent antiviral vaccines and have … 257 NCT01507103, a Phase II
study testing the therapeutic … 259 in patients with colorectal carcinoma, has been terminated …
study testing the therapeutic … 259 in patients with colorectal carcinoma, has been terminated …
The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer
F Qi, L Zhao, A Zhou, B Zhang, A Li, Z Wang… - Bioscience …, 2015 - jstage.jst.go.jp
… leucopenia in colorectal cancer patients treated with chemotherapy. … of anticancer, anti-inflammatory,
antioxidant, antiviral and … In addition, a phase II study was conducted to explore the …
antioxidant, antiviral and … In addition, a phase II study was conducted to explore the …
Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions
D Zamarin, P Palese - Future microbiology, 2012 - Future Medicine
… to improve antitumor activity of Newcastle disease virus. … innate antiviral immune responses
generated in these cells upon … of four patients with colorectal cancer, Hodgkin disease and …
generated in these cells upon … of four patients with colorectal cancer, Hodgkin disease and …